Religiosity and treatment response to antidepressant medication: a prospective multi-site clinical trial

The present study examined the relationship between religiosity/spirituality and treatment response to antidepressant medication (citalopram). One-hundred and forty-eight Caucasian and African-American adults with uncomplicated major depression were treated with citalopram (20-60 mg/day) over an eig...

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Bibliographic Details
Authors: Schettino, Jonathan R. (Author) ; Olmos, Natasha T. (Author) ; Myers, Hector F. (Author) ; Joseph, Nataria T. (Author) ; Poland, Russell E. (Author) ; Lesser, Ira M. (Author)
Format: Electronic Article
Language:English
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Published: Taylor & Francis 2011
In: Mental health, religion & culture
Year: 2011, Volume: 14, Issue: 8, Pages: 805-818
Further subjects:B Spirituality
B antidepressant
B Depression
B citalopram
B Religiosity
Online Access: Presumably Free Access
Volltext (lizenzpflichtig)

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520 |a The present study examined the relationship between religiosity/spirituality and treatment response to antidepressant medication (citalopram). One-hundred and forty-eight Caucasian and African-American adults with uncomplicated major depression were treated with citalopram (20-60 mg/day) over an eight-week period in a prospective multi-site clinical trial. Treatment response was assessed weekly with the Hamilton Rating Scale for Depression. Religiosity (i.e., religious behaviours) and spirituality (i.e., spiritual well-being) were assessed at week 3. No significant associations between spirituality and treatment response were found; however, there was a strong curvilinear relationship between religiosity and treatment response. Compared to lower or higher levels of religiosity, a moderate level of religiosity was significantly associated with a higher likelihood of remission and greater reduction in severity of depression. This association was independent of social support, ethnicity, gender, education, and baseline depression severity. A moderate amount of religiosity appears to be independently associated with an enhanced treatment response to citalopram. 
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