Time to Abolish the Forced Swim Test in Rats for Depression Research?
The forced swim test (FST) is a controversial rodent test that has been used for decades, mainly in depression studies. The severity of the procedure makes it ethically questionable and its validity has also been questioned. In this paper we contribute new data to this debate. We identified original...
| Authors: | ; ; ; |
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| Format: | Electronic Article |
| Language: | English |
| Check availability: | HBZ Gateway |
| Journals Online & Print: | Drawer...
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| Fernleihe: | Fernleihe für die Fachinformationsdienste |
| Published: |
Brill
2022
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| In: |
Journal of applied animal ethics research
Year: 2022, Volume: 4, Issue: 2, Pages: 170-178 |
| Further subjects: | B
rat
B 3Rs B alternatives to animal use B Depression B in silico B In vitro B forced swim test |
| Online Access: |
Volltext (kostenfrei) Volltext (kostenfrei) |
| Summary: | The forced swim test (FST) is a controversial rodent test that has been used for decades, mainly in depression studies. The severity of the procedure makes it ethically questionable and its validity has also been questioned. In this paper we contribute new data to this debate. We identified original research papers related to Major Depressive Disorder (MDD), using rats as models. We compared the citations received by studies that used the FST and by studies that did not, within subsequent human medical papers. The results show that the number of citations received by both groups was very low, but in the papers describing the FST data the median citation number was zero. Citation analysis indicates that the FST is not contributing significantly to the understanding or cure of MDD. We briefly review other approaches that overcome the ethical limitations of the FST, and which might also surpass its efficacy. |
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| ISSN: | 2588-9567 |
| Contains: | Enthalten in: Journal of applied animal ethics research
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| Persistent identifiers: | DOI: 10.1163/25889567-bja10026 |