Managing New Technology When Effective Control is Lost: Facing Hard Choices With CRISPR

This paper seeks to expand our appreciation of the gene editing tool, clustered regularly interspaced short palindromic repeats-associated protein 9 (CRISPR-Cas9), its function, its benefits and risks, and the challenges of regulating its use. I frame CRISPR's emergence and its current use in t...

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Bibliographic Details
Main Author: Zimbelman, Joel Andrew (Author)
Format: Electronic Article
Language:English
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Published: Wiley-Blackwell 2022
In: Journal of religious ethics
Year: 2022, Volume: 50, Issue: 3, Pages: 433-460
Further subjects:B CRISPR
B Frankenstein
B IVF
B genetic interventions
B gene editing
B genome engineering
B germline modifications
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Summary:This paper seeks to expand our appreciation of the gene editing tool, clustered regularly interspaced short palindromic repeats-associated protein 9 (CRISPR-Cas9), its function, its benefits and risks, and the challenges of regulating its use. I frame CRISPR's emergence and its current use in the context of 150 years of formal exploration of heredity and genetics. I describe CRISPR's structure and explain how it functions as a useful engineering tool. The contemporary international and domestic regulatory environment governing human genetic interventions is reviewed and shown to be increasingly ineffective in its ability to restrain, guide, and optimize the emerging use of CRISPR. Several reasons for this lack of consensus are discussed. In conclusion, I suggest a number of public policy recommendations that might allow us to simultaneously embrace our most important moral values and manage the inevitable power CRISPR will come to have in our lives.
ISSN:1467-9795
Contains:Enthalten in: Journal of religious ethics
Persistent identifiers:DOI: 10.1111/jore.12406